Exhibit significant activity fluorinated glucocorticoids dexamethasone, triamcinolone, fluotsinolon, flumetazon. Glucocorticoids cause a redistribution of body fat: increased deposition of fat on the face, neck, upper back, chest, stomach and decreases the fat layer on the limbs. The drug can be used to Intravenous Urogram Termination Of Pregnancy (Abortion) motor-ki of the stomach and intestines with their X-ray study. Glucocorticoids - vysokolipofilnye substance, easily penetrate the cell membrane, accurate and in the cytoplasm of cells associated with glucocorticoid receptors. Side effects of metformin: Lactic acidosis (increase in breast ki-slots in the blood plasma), pain in the heart and here shortness of breath and a metallic taste in the mouth, nausea, vomiting, diarrhea. Drug deoxycorticosterone dezoksikorton prescribed for Addison's disease (typically in combination with glucocorticoids), as well as myasthenia gravis. Relaxes the smooth muscles of the tracer and intestines. Sulfonylureas are used in diabetes mellitus type II. The highest level of glucocorticoids in blood plasma noted in 8 hours in the morning. Glucagon - a hormone that is produced ?kletkami islands Langergan-sa, stimulates glycogenolysis and gluconeogenesis in the liver and therefore increases the level of glucose in the blood plasma. Mineralocorticoid - hormone of the adrenal cortex, affecting the mineral indirect exchange, mainly on the exchange of sodium and potassium. This is Nerve Conduction Test to the fact that, in response to hyperglycemia is increased tracer which stimulates lipogenesis tracer inhibits lipolysis. Glucocorticoids may have a mild mineralocorticoid effect: delay in the body of sodium and increase excretion of potassium. Repaglinide (novonorm) is similar in action and the use of derivatives sulfonylureas. Synthesis of steroid hormones correlated. Glyukokortikoidretseptor complex trans-ported to the nucleus, where glucocorticoids influence on the expression of different genes, stimulating the formation of some proteins and breach-Shai education of others. When out of the excess production of mineralocorticoids arise: 1) swelling associated with an increase in the body of sodium and water retention, 2) increased blood pressure, 3) hypokalemia, which usually is accompanied by cardiac arrhythmias and weak Bost. Onset of action after 1,5 h; peak action 5-10 h duration of action - 12-16 hours Insulintsink crystal suspension is introduced just under the skin. Acarbose inhibits aglyukozidazy and prevents the absorption of carbohydrates. These drugs stimulate insulin secretion ??let?ami stop-dates of Langerhans. Metirapon violates formation of glucocorticoids and mineralocorticoids; used in Itsenko-Cushing syndrome. Derivatives of benzoic acid (meglitinidy). Pioglitazone appointed interior 1 time per day for type II diabetes. Pre-Preparata contraindicated in hepatic dysfunction, kidneys, blood system. Aminoglutethimide can be tracer with the syndrome Itsenko-Cushing (reduces the level of glucocorticoids and mineralocorticoids), and breast cancer tracer estrogen levels), prostate cancer (reduces androgen levels). Insulintsink amorphous suspension is introduced just under tracer skin, providing a honey-lennoe absorption of insulin from the injection site and respectively, over long periods. Injected under the skin for 15 min before meals 1 -3 times a day.
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